Hemodynamic factors in the pathogenesis and maintenance of hypertension. by Frohlich Ed.
Hypertension is not simply an acute elevation of arterial pressure during a laboratory experiment. It the development cardiovascular disorder provoking variety physiological adaptions brought about by imbalance pressor and depressor mechanisms that serve to control at normal levels in normotensive animal. These pathogenetic include hemodynamic, volume, renal parenchymal, sodium, renopressor, catecholamine, neural, hormonal, even factors. The most common form disease essential hypertension, affecting over 95% patients with hypertension. Although same, experimental animal model best mimics hypertension spontaneously hypertensive rat (SHR). However, state certainty SHR true duplicate inaccurate because causes both diseases remain unknown. Both forms are genetically predisposed, naturally occurring, slow but progressive development, similar hemodynamic adaptions. involve arteriolar venular constriction myocardial hypertrophy provide stable hyperfunctioning adaptation heart for substantial period time ultimately lead cardiac failure, stroke, other vascular impairment. At we can conclude they represent predisposed involves disarray multifactorial interplay usually maintain levels.
Read Hemodynamic factors in the pathogenesis and maintenance of hypertension. on OA.mg