K+ channels and cell cycle progression in tumor cells by Halima Ouadid-Ahidouch, Ahmed Ahidouch.
K(+) ions play a major role in many cellular processes. The deregulation of signaling is associated with variety diseases such as hypertension, atherosclerosis, or diabetes. are important for setting the membrane potential, driving force Ca(2+) influx, and regulate volume growing cells. Moreover, it increasingly recognized that channels control cell proliferation through novel mechanisms triggered modulated independently ion fluxes. In cancer, aberrant expression, regulation and/or sublocalization can alter downstream signals converge on cycle machinery. Various involved progression needed only at particular stages cycle. Consistent this idea, expression Eag1 HERG fluctuate along Despite acquired knowledge, our understanding functioning cancer cells requires further studies. These include identifying molecular controlling By how cells, we will gain insights into subvert need signal its targets to proliferate.
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