Science and latest papers
China′s Urbanization:Mechanism and Development Challenge by Zhou Weili.
It is essential to own a view of big pattern and think under the dynamic background development transition during study on China′s urbanization.From this standpoint,paradox appeared can be explained analyzed.By evaluating paradox china′s urbanization,this article examines endogenous mechanism more challenges development.
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Challenge to Reason by Andrew McLaughlin, C. West Churchman.
The Psychological Challenge of Late-Life Vision Impairment: Concepts, Findings, and Practical Implications by Hans-Werner Wahl.
The intention is to summarize the body of evidence speaking psychological challenges faced by visually impaired older adults, as well their coping efforts. This substantiated a rich set concepts, theories, and empirical findings that have accumulated under umbrella age-related psychoophthalmology (APO). I introduce field APO continue with discussion important concepts theories for better understanding adaptational processes in adults. then most relevant recent data from four areas: (1) everyday competence, (2) cognitive functioning, (3) social (4) subjective well-being-related outcomes, depression, processes. Thereafter, major insights related current state-of-the art psychosocial interventions visuallyimpaired adults are reviewed. close need public health community should become more aware address needs
Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies? by Tomasz Cierpicki, Jolanta Grembecka.
Over the past several years, there has been an increasing research effort focused on inhibition of protein-protein interactions (PPIs) to develop novel therapeutic approaches for cancer, including hematologic malignancies. These efforts have led development small molecule inhibitors PPIs, some which already advanced stage clinical trials while others are at different stages preclinical optimization, emphasizing PPIs as emerging and attractive class drug targets. Here, we review examples recently developed highly relevant cancers. We address existing skepticism about feasibility targeting emphasize potential benefit from blocking in then use these discuss successful identification PPI provide analysis interfaces, with goal ‘druggability’ new hematology. lessons learned improve success evaluate prospects limits this field. conclude that not all equally tractable by molecules, detailed interfaces is critical selection those highest chance success. Together, our uncovers patterns should help advance discovery malignancies PPIs.
Nursing administration in the 80s: the challenge and the satisfaction. by P Friend.
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The Challenge for Communities by Marilyn Taylor.
The Digital Work Environment-a Challenge and an Opportunity for CSCW. by Gerolf Nauwerck, Rebecka Cowen Forssell.
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Preservation of splenic tissue prevents postsplenectomy pulmonary sepsis following bacterial challenge by Charles D. Livingston, Barry A. Levine, Kenneth R. Sirinek.
Abstract Previous studies utilizing an intravenous method of bacterial challenge have failed to demonstrate a protective effect reimplanted splenic tissue. This bypasses the lungs, usual portal entry in postsplenectomy sepsis. In this study via lung was used investigate ability tissue protect against For purpose 203 rats were divided into four groups: total splenectomy, hemisplenectomy, sham-operated controls, and nonoperated controls. Two weeks postoperatively all challenged with either 1 × 105 or 5 106Streptococcus pneumoniae delivered transtracheal injection. Mortality rates observed for 2 weeks. At lower dose bacteria, no difference mortality among treatment groups. Similarly there 14-day at larger dose. higher dose, however, significant early (Days 1–9) between splenectomy group (100% mortality) other three groups (control 38%, sham control 25%, hemisplenectomy 25%). There two Unlike challenge, does not bypass pulmonary host-defense system, thus allowing interaction splenic-derived tuftsin antibody pulmonary-derived neutrophils macrophages, provides more suitable model spesis. Splenectomy shown result due sepsis, whereas preservation least half spleen reduced
From Knowledge-Based to Skill-Based Systems: Sailing as a Machine Learning Challenge by Pieter Adriaans.
AbstractThis paper describes the Robosail project. It started in 1997 with aim to build a self-learning auto pilot for single handed sailing yacht. The goal was make an adaptive system that would help sailor go faster on average race. Presently, after five years of development and number sea trials, we have commercial available (www.robosail.com). is hybrid using agent technology, machine learning, data mining rule-based reasoning. Apart from describing try generalize our findings, argue interesting paradigm class systems one could call Skill-based Systems.KeywordsHybrid SystemConstitutive RuleRegulative RuleSymbol GroundingSwivel AngleThese keywords were added by not authors. This process experimental may be updated as learning algorithm improves.
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177 tanks, 177 problems. Dealing with Hanford’s primary cleanup challenge