Preservation of splenic tissue prevents postsplenectomy pulmonary sepsis following bacterial challenge by Charles D. Livingston, Barry A. Levine, Kenneth R. Sirinek.
Abstract Previous studies utilizing an intravenous method of bacterial challenge have failed to demonstrate a protective effect reimplanted splenic tissue. This bypasses the lungs, usual portal entry in postsplenectomy sepsis. In this study via lung was used investigate ability tissue protect against For purpose 203 rats were divided into four groups: total splenectomy, hemisplenectomy, sham-operated controls, and nonoperated controls. Two weeks postoperatively all challenged with either 1 × 105 or 5 106Streptococcus pneumoniae delivered transtracheal injection. Mortality rates observed for 2 weeks. At lower dose bacteria, no difference mortality among treatment groups. Similarly there 14-day at larger dose. higher dose, however, significant early (Days 1–9) between splenectomy group (100% mortality) other three groups (control 38%, sham control 25%, hemisplenectomy 25%). There two Unlike challenge, does not bypass pulmonary host-defense system, thus allowing interaction splenic-derived tuftsin antibody pulmonary-derived neutrophils macrophages, provides more suitable model spesis. Splenectomy shown result due sepsis, whereas preservation least half spleen reduced
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