discovery

THE DISCOVERY OF TANGSHANG AU DEPOSIT OF AU POLYMINERALIZATION,GUANGNA

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THE DISCOVERY OF TANGSHANG AU DEPOSIT OF AU POLYMINERALIZATION,GUANGNA by Yang Chang-hua.

Various usual metallogenetic types of Dian-Qian-Gui Au triangle region are concentrated in an area less than 10 km~2,ie,Au deposit micro-fine dissemination;Au on unconformity(Dachang Bed);Au basic volcanite;Au volcanic clastic sedimentary type;Au quartz vein type;and placer present river sediment,which have different ore guide.

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Reactive Metabolite Screen for Reducing Candidate Attrition in Drug Discovery

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Reactive Metabolite Screen for Reducing Candidate Attrition in Drug Discovery by Weichao G. Chen, Chenghong Zhang, Michael J. Avery, Hassan G. Fouda.

Toxicity of drug candidates accounts for a significant portion attrition during exploratory development. One common mode toxicity is the formation electrophilic reactive metabolites, which manifest their by covalent binding to nucleophilic groups present in vital cellular proteins and nucleic acids (1–2). Although not all toxicological manifestations are attributable vast body literature suggests that inadequate detoxification chemically metabolites formed as result bioactivation pathogenic mechanism tissue necrosis (3–4), carcinogenicity (5), teratogenicity (6) immune-mediated (7).KeywordsValproic AcidNeutral LossCovalent BindingReactive MetabolitePyroglutamic AcidThese keywords were added machine authors. This process experimental may be updated learning algorithm improves.

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The Discovery of My Completeness Proofs

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The Discovery of My Completeness Proofs by Leon Henkin.

§1. Introduction . This paper deals with aspects of my doctoral dissertation which contributed to the early development model theory. What was use later workers less results thesis, than method by I proved completeness first-order logic—a result established Kurt Gödel in his thesis 18 years before. The ideas that fed discovery this proof were mostly those found teachings and writings Alonzo Church. may seem curious, as work logic, teaching, gave great emphasis constructive character mathematical while theory is filled theorems about very large classes structures, whose proofs often by-pass methods. Another curious thing a new Gödel’s theorem, it arrived midst efforts prove an entirely different result. Such “accidental” discoveries arise many parts scientific work. Perhaps there are regularities conditions under such “accidents” occur would interest some historians, so shall try describe detail accident befell me. A idea, or complex ideas, have been set forth certain circumstances. process consists selecting input somehow combining transforming them produce output ideas. produces particular thus be represented diagram one sees science; “black box” lines coming from left represent going out right representing output. To must explain what occurs inside box, i.e., how outputs obtained inputs.

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Guiding children towards mathematical discovery, (3rd edition), by Leonard M. Kennedy. Pp 533. £9·10. 1980. ISBN 0-534-00757-0 (Wadsworth)

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Guiding children towards mathematical discovery, (3rd edition), by Leonard M. Kennedy. Pp 533. £9·10. 1980. ISBN 0-534-00757-0 (Wadsworth) by Janet Duffin.

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PENGEMBANGAN LEMBAR KERJA SISWA (LKS) BERBASIS DISCOVERY LEARNING TERHADAP PEMAHAMAN KONSEP MATEMATIS SISWA

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PENGEMBANGAN LEMBAR KERJA SISWA (LKS) BERBASIS DISCOVERY LEARNING TERHADAP PEMAHAMAN KONSEP MATEMATIS SISWA by Melia Roza, Majidah Khairani.

Penelitian ini bertujuan untuk mengembangkan Lembar Kerja Siswa (LKS) berbasis  Discovery Learning terhadap pemahaman konsep matematis bagi siswa kelas VII SMP N 3 Talamau Kabupaten Pasaman Barat. merupakan penelitian pengembangan dengan menggunakan model 4D yang dimodifikasi menjadi 3D yaitu define, design, dan develop. Pada tahap define dilakukan analisis kebutuhan, siswa, materi, kurikulum. design pemilihan bahan ajar dikembangkan, menentukan format LKS berdasarkan hasil dilakukan. Kemudian develop, pada ujicoba produk orang evaluasi perorangan, 8 kelompok kecil, 30 uji lapangan. Hasil menunjukkan bahwa Discovery dikembangkan telah valid nilai rata-rata 80,40% berada kategori valid. Nilai praktikalitas diperoleh dari angket respon guru 87,5% 87,891% sangat praktis. efektifitas ujian akhir bab (post-test) 81,832% efektif. Dapat disimpulkan Barat  dihasilkan sudah valid, praktis,

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Structure-based Virtual Screening Approaches in Kinase-directed Drug Discovery

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Structure-based Virtual Screening Approaches in Kinase-directed Drug Discovery by Dávid Bajusz, György G. Ferenczy, György M. Keserű.

Protein kinases are one of the most targeted protein families in current drug discovery pipelines. They implicated many oncological, inflammatory, CNS-related and other clinical indications. Virtual screening is a computational technique with diverse set available tools that has been shown times to provide novel starting points for kinase-directed discovery. This review starts concise overview function, structural features inhibitory mechanisms kinases. In addition briefly reviewing practical aspects structure-based virtual screenings, we discuss several case studies illustrate state art type I, II, allosteric (type III-V) covalent VI) kinase inhibitors. With this review, strive summary latest advances inhibitors, as well tool anyone who wishes embark on such an endeavor.

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Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments

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Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments by Francesco Nannini, Lenart Senicar, Farhaan Parekh, Khai Kong, Alexander Kinna, Reyisa Bughda, James Sillibourne, Xihao Hu, Biao Ma, Yuchen Bai, Mathieu Ferrari, Martin Pule, Shimobi Onuoha.

Phage display technology in combination with next-generation sequencing (NGS) currently is a state-of-the-art method for the enrichment and isolation of monoclonal antibodies from diverse libraries. However, current NGS methods employed phage libraries are limited by short contiguous read lengths associated second-generation platforms. Consequently, identification antibody sequences has conventionally been restricted to individual domains or analysis single domain binding moieties such as camelid VHH cartilaginous fish IgNAR antibodies. In this study, we report application third-generation address limitation. We used molecule real time (SMRT) coupled hairpin adaptor loop ligation facilitate accurate interrogation full-length single-chain Fv (scFv) Our facilitated rapid testing scFv enriched within days following panning. Two against CD160 CD123 were panned monitored NGS. Analysis data sets led several functional that not identified conventional panning screening strategies. approach, which combines selection immune fragments, an easy discover antibodies, range affinities biophysical characteristics.

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