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Familial hyper- and hypouricemias in random and hyperlipidemic recall cohorts: The Princeton School District Family Study by Peter M. Laskarzewski, Philip R. Khoury, John A. Morrison, Kathe Kelly, Charles J. Glueck.

Using the Princeton School Family Study, our specific aim was to estimate prevalence of familial hyper- and hypouricemia, proportion probands’ first-degree relatives who were similarly affected, evaluate contribution diseases, drugs, alcohol intake (if any) uric acid levels. We studied 379 probands a total 1928 subjects, 125 52 black from randomly recalled group, 147 white 55 hyperlipidemic recall (top decile cholesterol and/or triglyceride) group. Familial hypouricemias arbitrarily identified in those kindreds having at least two same as proband, top or bottom respectively, for serum acid. No had symptomatic gout. Diseases, not consistently associated with aggregations high low levels families, little relationship individuals. Of 177 probands, none hyperuricemia. group their kindreds, 2 hyperuricemia, concurrent primary hyperlipoproteinemia hypertension. hypouricemia present 1 3 kindreds. While clustering hyperuricemia limited, much more marked. Seventy-four 84% respectively hypouricemic < 50th percentile. In there significant inverse partial correlations between density lipoprotein cholesterol. Inverse associations concurrence hypertension hyperuricemic families points importance blood pressure screening asymptomatic The potential ramifications within-family need be further assessed populations, particularly regards nephrolithiasis.

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